1-MNA

Description

*It is recommended to consult with a physician before taking Endotelio 1-MNA.*

Harness the power of the Molecule of the Future with 1-MNA, a natural clinically proven way to safely enhance NAD levels and support cellular longevity. With over 20 years of research and endorsed by 250+ clinicians, this patented supplement is crafted to improve energy, vascular health, and cellular resilience, paving the way for a healthier lifestyle.

1-MNA, which stands for 1-methylnicotinamide, is a natural byproduct of nicotinic acid and nicotinamide, both primary variants of vitamin B3. Research indicates that 1-MNA plays a role in supporting the health of the vascular endothelium and the cardiovascular system. Given its potential in minimizing the onset of atherosclerosis, it’s considered beneficial as a dietary supplement, especially for older individuals.

1-MNA is a compound naturally produced in our bodies, primarily in the liver, as it’s a byproduct of nicotinic acid and nicotinamide metabolism. While it’s also found in vitamin B3-rich foods, dietary sources contribute minimally to the total amount of 1-MNA present in the human body. In fact, around 60% of the niacin we consume is transformed into 1-MNA, as cited by Menon et al., 2007.

Derived from vitamins, 1-MNA is a natural and physiological substance.
Known to be safe and well-tolerated.
Renowned for its anti-inflammatory and anti-atherosclerotic qualities.
Lowers levels of inflammatory markers.
Essential for maintaining vascular endothelial function and stimulating synthesis of prostacyclin (PGI2).
Bolsters the secretory function of the vascular endothelium, thereby safeguarding against dysfunction.
Minimizes the risk of blood clot formation and inflammation via PGI2 synthesis.
Enhances the stability of sirtuins (Sirt1), which in certain biological models has been associated with extended lifespan.
Considered a groundbreaking molecule with potent anti-inflammatory and anti-atherosclerotic effects.
Leading research institutions suggest 1-MNA may extend human lifespan

In humans, 1-MNA is predominantly produced in the liver during niacin metabolism. This production stems from the enzymatic breakdown of nicotinamide, facilitated by nicotinamide N-methyltransferase (NNMT) (as referenced by Felsted and Chaykin, 1967; Pissios, 2017). Once synthesized, 1-MNA converts into pyridones: 2-PYR and 4-PYR. Although both are generated, 2-PYR is the principal metabolite of 1-MNA in humans, as noted by Sugihara et al., 2005.